The Group L encounter at the Philadelphia Stadium finds Ghana in second place with four points, trailing group leaders England on goal difference after a 1-1 draw on Tuesday, June 23. Croatia sits third with three points and must win to ensure automatic qualification.
A victory could see Carlos Queiroz’s Ghana side top the group, provided England drop points against Panama. The four-time African champions are attempting to reach the tournament's knockout phase for the first time since their quarter-final run in 2010.
Ghana face uncertainty in goal as first-choice goalkeeper Lawrence Ati Zigi remains a doubt with a muscle injury sustained during their opening match against Panama.
Benjamin Asare is expected to retain his spot after a three-save performance against England. Captain Jordan Ayew is tipped to lead the attack, though he faces pressure from forward Prince Kwabena Adu.
Croatia manager Zlatko Dalic has a fully fit squad but faces selection dilemmas in the forward line. Striker Ante Budimir is pushing for a starting role ahead of Petar Musa after scoring the winning goal against Panama off the bench.
Defender Josko Gvardiol is expected to start despite being substituted at halftime during Croatia's last match.
Kick-off is scheduled for 2100 GMT.

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